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Aß (1-40) together with Aß (1-42) are two major C-terminal variants of the Aß protein constituting the majority of Aßs. These undergo post-secretory aggregation and deposition in the Alzheimer’s disease brain.
Electron microscopy of b-amyloid (1-40) stained with Thioflavin T (data generated by an AnaSpec scientist).
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Citations
Combined Treatment with a BACE Inhibitor and Anti-Aβ Antibody Gantenerumab Enhances Amyloid Reduction in APPLondon Mice
J Neurosci . 2014 Aug 27 ;34(35) 11621 | DOI : 10.1523/JNEUROSCI.1405-14.2014
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Microglial Amyloid-1-40 Phagocytosis Dysfunction Is Caused by High-Mobility Group Box Protein-1: Implications for the Pathological Progression of Alzheimer’s Disease
Int J Alzheimers Dis . 2012 Feb 24 ;2012 11 | DOI : http://dx.doi.org/10.1155/2012/685739
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A screening UHPLC–MS/MS method for the analysis of amyloid peptides in cerebrospinal fluid of preclinical species
Bioanalysis . 2010 Dec 23 ;3(1) 45 | DOI : 10.4155/bio.10.163
Regulation of Matrix Metalloproteinase 2 by Oligomeric Amyloid β Protein
Brain Res . 2011 Mar 02 ;1387 141 | DOI : 10.1016/j.brainres.2011.02.078
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Structural and functional alterations in amyloid-β precursor protein induced by amyloid-β peptides
J Alzheimers Dis . 2014 Apr 28 ;25(3) 547 | DOI : 10.3233/JAD-2011-101938
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CpG-ODNs induces up-regulated expression of chemokine CCL9 in mouse macrophages and microglia
Cellular Immuno . 2010 Jan 01 ;260(2) 113 | DOI : https://doi.org/10.1016/j.cellimm.2009.10.001
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Gelsolin Restores A-Induced Alterations in Choroid Plexus Epithelium
J Biomed and Biotech . 2010 Jan 19 ;2010 7 | DOI : http://dx.doi.org/10.1155/2010/805405
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Mutant presenilin 1 increases the expression and activity of BACE1
JBC . 2009 Feb 05 ;284 9027 | DOI : 10.1074/jbc.M805685200
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Spatial Memory Impairment Without Apoptosis Induced by the Combination of Beta-Amyloid Oligomers and Cerebral Ischemia Is Related to Decreased Acetylcholine Release in Rats
J Pharmacol Sci . 2007 Nov 13 ;106 84 | DOI : 10.1254/jphs.fp0071648
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Aβ and tau form soluble complexes that may promote self aggregation of both into the insoluble forms observed in Alzheimer's disease
PNAS . 2006 Feb 07 ;103(6) 1953 | DOI : https://doi.org/10.1073/pnas.0509386103
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CLAC Binds to Amyloid β Peptides through the Positively Charged Amino Acid Cluster within the Collagenous Domain 1 and Inhibits Formation of Amyloid Fibrils
JBC . 2004 Dec 21 ;280 15484 | DOI : 10.1074/jbc.M413340200
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Effects of hydroxyl group variations on a flavonoid backbone toward modulation of metal-free and metal-induced amyloid-β aggregation
Inorg. Chem. Front. . 2016 Jan 13 ;3 381 | DOI : 10.1039/C5QI00219B
- HJ. Lee
Cilostazol suppresses β‐amyloid production by activating a disintegrin and metalloproteinase 10 via the upregulation of SIRT1‐coupled retinoic acid receptor‐β
J Neurosci Res. . 2014 Jun 05 ;92(11) 1581 | DOI : 10.1002/jnr.23421
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Insights into antiamyloidogenic properties of the green tea extract (-)-epigallocatechin-3-gallate toward metal-associated amyloid-β species.
Proc Natl Acad Sci U S A . 2013 Feb 20 ;110(10) 3743 | DOI : 10.1073/pnas.1220326110
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Bapineuzumab captures the N-terminus of the Alzheimer's disease amyloid-beta peptide in a helical conformation
Scientific Rpt . 2013 Feb 18 ;3 | DOI : 10.1038/srep01302
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Effects of NK-4 in a Transgenic Mouse Model of Alzheimer's Disease
PLoS One. . 2012 Jan 04 ;7(1) e30007 | DOI : https://doi.org/10.1371/journal.pone.0030007
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Quantitation of amyloid beta peptides in CSF by surface enhanced MALDI-TOF
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Microglial Amyloid-β1-40 Phagocytosis Dysfunction is Caused by High-Mobility Group Box Protein-1: Implications for the Pathological Progression of Alzheimer’s Disease
Int J Alz Dis . 2012 May 08 ;2012 685739 | DOI : https://doi.org/10.1155/2012/685739
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Somatostatin modulates insulin-degrading-enzyme metabolism: Implications for the regulation of microglia activity in AD
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Synthesis and characterization of IMPY derivatives that regulate metal-induced amyloid-β aggregation
Metallomics. . 2011 Jan 06 ;3(3) 284 | DOI : 10.1039/c0mt00077a
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Inhibition of amyloid-β aggregation by coumarin analogs can be manipulated by functionalization of the aromatic center
Bioorg Med Chem. . 2011 Mar 12 ;19(8) 2596 | DOI : 10.1016/j.bmc.2011.03.010
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A partially folded structure of amyloid-beta(1-40) in an aqueous environment.
Biochem Biophys Res Commun . 2011 Jun 25 ;411(2) 312 | DOI : 10.1016/j.bbrc.2011.06.133
- S. Vivekanandan
Neuroprotective effect of honokiol and magnolol, compounds from Magnolia officinalis, on beta-amyloid-induced toxicity in PC12 cells
Phytother Res. . 2010 Jun 01 ;24(10) 1538 | DOI : 10.1002/ptr.3178
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Gelsolin Restores Aβ-Induced Alterations in Choroid Plexus Epithelium
J Biomed Biotechnol . 2010 Mar 25 ;2010 805405 | DOI : https://doi.org/10.1155/2010/805405
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Comparative study of inhibition at multiple stages of amyloid-β self-assembly provides mechanisitic insight
Mol Pharmacol. . 2009 May 29 ;76(2) 405 | DOI : 10.1124/mol.109.055301
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Dynamic fluorescence imaging analysis to investigate the cholesterol recruitment in lipid monolayer during the interaction between beta-amyloid (1-40) and lipid monolayers.
Colloids Surf B Biointerfaces. . 2009 Jun 23 ;74(1) 59 | DOI : 10.1016/j.colsurfb.2009.06.027
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Differential modification of Cys10 alters transthyretin's effect on beta-amyloid aggregation and toxicity
Protein Eng Des Sel . 2009 Jun 23 ;22(8) 479 | DOI : 10.1093/protein/gzp025
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The cleavage products of amyloid-β precursor protein are sorted to distinct carrier vesicles that are independently transported within neurites
J Neurosci. . 2009 Mar 18 ;29(11) 3565 | DOI : 10.1523/JNEUROSCI.2558-08.2009
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Simvastatin protects against amyloid β and HIV-1 tat-induced promoter activities of inflammatory genes in brain endothelial cells
Mol Pharmacol . 2008 Feb 14 ;73(5) 1424 | DOI : 10.1124/mol.107.042028
- IE. Andras
Bio-assay guided isolation and identification of anti-Alzheimer active compounds from the root of Angelica sinensis
Food Chem . 2008 Sep 23 ;114(1) 246 | DOI : https://doi.org/10.1016/j.foodchem.2008.09.046
- CC. Ho
Identifying the minimal copper- and zinc-binding site sequence in amyloid-β peptides
J Biol Chem . 2008 Jan 30 ;283(16) 10784 | DOI : 10.1074/jbc.M707109200
- V. Minicozzi
Enzymatic characteristics of I213T mutant presenilin-1/gamma-secretase in cell models and knock-in mouse brains: familial Alzheimer disease-linked mutation impairs gamma-site cleavage of amyloid precursor protein C-terminal fragment beta.
J Biol Chem . 2008 Apr 21 ;283(24) 16488 | DOI : 10.1074/jbc.M801279200
- M. Shimojo
Activation of 5-HT4 receptors inhibits secretion of β peptides and increase neuronal survival
Exp Neurol. . 2016 Sep 15 ;203(1) 274 | DOI : 10.1016/j.expneurol.2006.07.021
- S. Cho
Soluble aggregates of the amyloid-β protein activate endothelial monolayers for adhesion and subsequent transmigration of monocyte cells
J Neurochem . 2007 Oct 22 ;104(2) 500 | DOI : 10.1111/j.1471-4159.2007.04988.x
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Role of aggregation conditions in structure, stability, and toxicity of intermediates in the Aβ fibril formation pathway
Protein Sci . 2007 Apr 01 ;16(4) 723 | DOI : 10.1110/ps.062514807
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Early-onset behavioral and synaptic deficits in a mouse model of Alzheimer's disease
PNAS . 2006 Mar 28 ;103(13) 5161 | DOI : https://doi.org/10.1073/pnas.0600948103
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Protofibril Formation of Amyloid β-Protein at Low pH via a Non-cooperative Elongation Mechanism
J Biol Chem . 2005 May 28 ;280(34) 30001 | DOI : 10.1074/jbc.M500052200
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Elucidating the Kinetics of β-Amyloid Fibril Formation
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Specific binding of amyloid-β-protein to IMR-32 neuroblastoma cell membrane
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Cholesterol depletion inhibits the degradation of amyloid beta-peptide in rat pheochromocytoma (PC12) cells.
Neurosci Lett. . 2005 Sep 09 ;391(1-2) 71 | DOI : 10.1016/j.neulet.2005.08.034
- XZ. Sun
Transglutaminase catalyzes differential crosslinking of small heat shock proteins and amyloid-β
FEBS Lett . 2004 Oct 08 ;576(1-2) 57 | DOI : 10.1016/j.febslet.2004.08.062
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Rapid method for measurement of surface tension in multiwell plates
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Insertion of Alzheimer's Aβ40 Peptide into Lipid Monolayers
Biophys J. . 2004 Sep 01 ;87(3) 1732 | DOI : 10.1529/biophysj.104.043265
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Glypican-1 as an Aβ binding HSPG in the human brain: Its localization in DIG domains and possible roles in the pathogenesis of Alzheimer’s disease
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Targeted control of kinetics of β-amyloid self-association by surface tension-modifying peptides
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Humanin peptides block calcium influx of rat hippocampal neurons by altering fibrogenesis of Aβ(1–40).
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Cholesterol Is an Important Factor Affecting the Membrane Insertion of β-Amyloid Peptide (Aβ1–40), Which May Potentially Inhibit the Fibril Formation
JBC . 2001 Dec 10 ;277(8) 6273 | DOI : 10.1074/jbc.M104146200
- SR. Ji
A novel compound RS-0466 reverse β-amyloid-induced cytotoxcity through the Akt signaling pathway in vitro
Eur J Pharmacol. . 2012 Dec 13 ;457(1) 11 | DOI : 10.1016/s0014-2999(02)02657-2
- Y. Nakagami
β-amyloid peptide-induced apoptosis regulated by a novel protein containing a G protein activation module
J Biol Chem. . 2001 Feb 20 ;276(22) 18748 | DOI : 10.1074/jbc.M011161200
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Inflammatory cytokine levels are influenced by interactions between THP-1 monocytic, U-373 MG astrocytic, and SH-SY5Y neuronal cell lines of human origin
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Structure−function relationships for inhibitors of β-amyloid toxicity containing the recognition sequence KLVFF
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A mathematical model of the kinetics of β-amyloid fibril growth from the denatured state
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Interaction between β-amyloid and lens αB-crystallin
FEBS Lett . 2000 Nov 03 ;484(2) 98 | DOI : https://doi.org/10.1016/S0014-5793(00)02136-0
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Expression of prostaglandin E synthase mRNA is induced in beta-amyloid treated rat astrocytes
Neurosci Lett . 2000 Apr 14 ;283(3) 221 | DOI : 10.1016/s0304-3940(00)00926-5
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The Molecular Chaperone αB-crystallin Enhances Amyloid β Neurotoxicity
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Complement-dependent proinflammatory properties of the Alzheimer's disease β-peptide
JEM . 1998 Aug 03 ;188(3) 431 | DOI : https://doi.org/10.1084/jem.188.3.431
- BM. Bradt
Effect on memory of acute administration of naturally secreted fibrils and synthetic amyloid-beta peptides in an invertebrate model.
Neurobiol Learn Mem . 2007 Oct 24 ;89(4) 407 | DOI : 10.1016/j.nlm.2007.08.011
- M. Feld
Identifying the minimal Cu and Zn binding site sequence in amyloid beta peptides.
J Biol Chem . 2008 Jan 30 ;283(16) 10784 | DOI : 10.1074/jbc.M707109200.
- V. Minicozzi
Microchip electrophoresis profiling of Aβ peptides in the cerebrospinal fluid of patients with Alzheimer’s disease.
Anal Chem . 2010 Sep 15 ;82(18) 7611 | DOI : 10.1021/ac101337n
- M. Reza
Beta-amyloid peptide blocks the fast-inactivating K+ current in rat hippocampal neurons.
Biophys J 70, 296. . 1996 Jan 01 ;70(1) 296 | DOI : 10.1016/S0006-3495(96)79570-X
- TA. Good
Cholesterol depletion inhibits the degradation of amyloid β-peptide in rat pheochromocytoma (PC12) cells.
Neurosci. Lett. . 2005 Sep 09 ;391(1-2) 71 | DOI : 10.1016/j.neulet.2005.08.034.
- ZX. Sun
A novel compound RS-0466 reverses β-amyloid-induced cytotoxicity through the Akt signaling pathway in vitro.
Eur J Pharmacol . 2002 Dec 13 ;457(1) 11 | DOI : 10.1016/s0014-2999(02)02657-2
- Y. Nakagami
N-truncation and pyroglutaminylation enhances the opsonizing capacity of Aβ-peptides and facilitates phagocytosis by macrophages and microglia.
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Quantification of Amyloid-β in Plasma by Simple and Highly Sensitive Immunoaffinity Enrichment and LC-MS/MS Assay
J Applied Lab Med . 2021 Jul 01 ;6(4) 834 | DOI : https://doi-org.lib-proxy.fullerton.edu/10.1093/jalm/jfaa225
- T. Iino
- et al
References
Aging renders the brain vulnerable to amyloid beta-protein neurotoxicity
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Amyloid plaque core protein in Alzheimer disease and Down syndrome
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Amyloid β-Protein (Aβ) 1–40 But Not Aβ1–42 Contributes to the Experimental Formation of Alzheimer Disease Amyloid Fibrils in Rat Brain
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